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Additional Information
 

Mechanistic Rationale

HDAC6 inhibitor treatment will prevent tau aggregation and stop or slow the progression of AD

Healthy neurons

Neurons contain

microtubules, which

perform important

transport functions

Acetylated tau proteins provide structure to microtubules and support axonal transport.

Dysfunctional neurons

HDAC6 deacetylates tau, which becomes unbound from microtubules. Free tau becomes phosphorylated.

Eventually, tau becomes hyper-phosphorylated, which leads to neurofibrillary tangles(NFTs).

Tangles accumulate

within neurons,

microtubules fail to

function and eventually neurons die.

HDAC6 inhibitor treatment will preserve axonal transport and stop or slow the progression of AD and ALS

Neurons contain microtubules, which perform important transport functions.

Acetylated tau and tubulin proteins provide structure to microtubules and support axonal transport

HDAC6 deacetylates tau and tubulin, which makes microtubules less resilient and axonal transport is disrupted.